Axl Receptor Tyrosine Kinase

Axl (also known as Ark, Ufo, and Tyro7) is the prototype of a family of transmembrane receptor tyrosine kinases, which also includes Tyro3 and Mer, that bind to the vitamin K-dependent protein ligands growth arrest-specific gene 6 (Gas6), and protein S. Axl, Tyro3, and Mer are variably expressed in neural, lymphoid, vascular, and reproductive tissues and in different primary cells and tumor cell lines. Recent studies indicate that Axl plays an important role in vascular biology, cell growth and protection from apoptosis in normal and cancer cells. Axl activation results in autophosphorylation and phosphorylation of cytoplasmic substrates, including phosphatidylinositol 3-kinase (PI-3K), Akt, S6K, Src kinase, ERK, p38, STAT3, and NF-kappaB.

Gankyrin is an oncoprotein with potent cell cycle and apoptotic properties that is overexpressed in hepatocarcinogenesis and in hepatocellular carcinomas.  It is known to play a role in the regulation of the phosphorylation of the retinoblastoma protein by CDK4, and to enhance the ubiquitinylation of p53 by MDM2.
Gankyrin was recently found to be a component of the 26S proteasome. This suggests a biochemical pathway by which gankyrin may not only control  the rate of p53 ubiquitinylation through MDM2 but may also act as an adaptor protein that delivers p53 to the 26S proteasome for degradation. 

Gankyrin, His₆-tagged (Cat. # UW9815)

USP2 Fragment [271-618], untagged (Cat. # UW9850)
USP2 is a deubiquitinating enzyme overexpressed in cancer cells. Inhibition of USP2 results in apoptosis of transformed prostate cells.